姓 名: 刘玉霞

职 称: 讲师

研究方向：糖生物学和糖工程

电子邮件: yuxialiu@nwu.edu.cn

简 介：

刘玉霞，中共党员，博士（后），讲师，硕士生导师，研究方向为营养糖生物学和糖工程，具体包括：功能性低聚糖的制备、分析、结构解析及结构与功能关系研究；糖芯片构建新方法的开发、天然寡糖芯片构建及其应用研究。先后在Carbohydrate Polymers、npj Biofilms and Microbiomes、Analytical Chemistry、Journal of Agricultural and Food Chemistry、Food Chemistry、Journal of Biological Macromolecules、Catalysis Science & Technology、Chemistry-A European Journal等国际学术期刊发表SCI论文23篇，其中第一作者7篇，通讯作者3篇，授权发明专利2项，申请受理发明专利1项。主持国家自然科学基金青年项目1项，主持中国博士后基金面上二等资助项目1项，主持陕西基础科学（化学、生物学）研究院青年项目1项，参与国家自然科学基金面上项目3项，参与陕西省科技创新团队等项目2项。目前任Asian Journal of Organic Chemistry审稿人。

近5年主持科研项目：

[1] 双功能手性双核铜催化四氢异喹啉的需氧不对称交叉脱氢偶联反应研究，21902126，国家自然科学基金青年项目，2019年8月，主持。

[2] 黏蛋白型O-糖芯片构建及幽门螺旋杆菌结合糖链筛选研究，2019M663947XB，中国博士后“西部地区博士后人才资助计划”面上项目，2019年11月，主持。

[3] 陕西基础科学（化学、生物学）研究院基础科学研究计划青年项目，黏蛋白O-糖链芯片的构建及其在鼠伤寒沙门氏菌粘附受体靶点筛选中的应用，23JHQ040, 2024年5月，主持。

获奖情况：

教学获奖

[1] 第三届青年教师讲课比赛，古天乐代言太阳集团138，优秀奖，2023年。

[2] 参与指导学生获得中国国际大学生创新大赛（2024），校级金奖，2024年。

近5年代表性研究论文:

已发表的学术论文：

（1）Liu, Yuxia; Yang, Tong; Rong, Jinqiao; Yuan, Jinhang; Fan, Jiangbo; Man, Lijuan; Wei, Ming; Lan Yao; Liu, Yinchuan; Gong Guiping; Lu Yu; Song, Xuezheng; Huang, Linjuan*; Wang, Zhongfu*. Integrated analysis of natural glycans using a versatile pyrazolone-type heterobifunctional tag ANPMP. Carbohydrate Polymers, 2024, 327: 121617.

（2）Li, Cheng; Chen, Qinghui; Rong, Jinqiao; He, Houde; Lu, Yu; Liu, Yuxia*; Zhongfu Wang*. LC-MS Characterization of N/O-Glycans of α- and β-subunits of Chicken Ovomucin Separated by SDS-PAGE. Analytical Biochemistry, 2024, 694: 115625.

（3）Liu, Yuxia*; Yan, Yonggang; Xue, Dong; Wang, Zhongfu; Xiao, Jianliang; Wang, Chao*. Highly efficient binuclear copper-catalyzed oxidation of N,N-Dimethylanilines with O₂. ChemCatChem, 2020, 12(8): 2221-2225.

（4）Liu, Yuxia*; Wang, Chao; Huang, Linjuan; Xue, Dong*. Room-temperature Palladium(II)-catalyzed direct 2-arylation of indoles with tetraarylstannanes. Synlett, 2020, 31(16): 1613-1618.

（5）Liu, Yuxia; Xue, Dong; Li, Chaoqun; Xiao, Jianliang; Wang, Chao*. Reactions catalyzed by a binuclear copper complex: selective oxidation of alkenes to carbonyls with O₂. Catalysis Science & Technology, 2017, 7(23): 5510-5514.

（6）Liu, Yuxia; Wang, Chao*; Xue, Dong; Xiao, Miao; Li, Chaoqun; Xiao, Jianliang*. Binuclear copper complex catalysed reactions: aerobic cross dehydrogenative coupling of N-aryltetrahydroisoquinolines. Chemistry - A European Journal, 2017, 23(13): 3051-3061.

（7）Liu, Yuxia; Wang, Chao*; Xue, Dong; Xiao, Miao; Liu, Jiao; Li, Chaoqun; Xiao, Jianliang*. Binuclear copper complex catalysed reactions: relay aerobic oxidation of N-aryltetrahydroisoquinolines to dihydroisoquinolones with a VB1 analogue. Chemistry - A European Journal, 2017, 23(13): 3062-3066.

（8）Zou, Meiyi; Liu, Yuxia; Man, Lijuan; Lan, Yao; Wei, Qian; Jin, Wanjun; Chen, Qinghui; Jia, Yue; Yao, Xinbo; Lu, Yu; Huang, Linjuan; Wang, Zhongfu*; Wang, Chengjian*. Comprehensive comparison of bioactive N-glycans among seven species of livestock and poultry plasma using a relative quantification strategy. Journal of Agricultural and Food Chemistry, 2023, 71(48): 19088-1910.

（9）Wei, Ming; Huang, Linjuan; Liu, Yuxia; Jin, Wanjun; Yao, Xinbo; Rong, Jinqiao; Bai, Fan; Song, Xuezheng*; Wang, Zhongfu*. Strategy for isolation, preparation, and structural analysis of chondroitin sulfate oligosaccharides from natural sources. Analytical Chemistry, 2020, 92(17): 11644-11653.

（10）Zhong, Peiyun; Yang, Yuerong; Han, Tianjiao; Huang, Wenqi; Liu, Yuxia; Gong, Guiping; Huang, Linjuan; Lu, Yu*; Wang, Zhongfu*. Comparative Analysis of Free and Glycoconjugates Oligosaccharide Content in Milk from Different Species. Journal of Agricultural and Food Chemistry, 2024, 72(1): 670-678.

（11）Han, Jianli; Qinghui Chen; Jin, Wanjun; Zou, Meiyi; Lu, Yu; Liu, Yuxia; Wang, Chengjian; Wang, Zhongfu; Linjuan Huang*. Purification of N- and O-glycans and their derivatives from biological samples by the absorbent cotton hydrophilic chromatographic column. Journal of Chromatography A. 2020, 1620: 461001.

（12）Huang, Wenqi; Xie Yutao; Guo, Tongyi; Dai, Wei; Nan, Linhua; Wang, Qian; Liu, Yuxia; Lan Wenxian; Wang, Zhongfu; Huang, Linjuan*; Guiping Gong*. A new perspective on structural characterisation and immunomodulatory activity of arabinogalactan in Larix kaempferi from Qinling Mountains. 2024, 265: 130859.

（13）Impact of structurally diverse polysaccharides on colonic mucin O-glycosylation and gut microbiota. Zhao, Tong; Zhang, Yue; Nan, Linhua; Zhu, Qing; Wang, Shukai; Xie, Yutao; Dong, Xinling; Cao, Cui; Lin, Xiaoliang; Lu, Yu; Liu, Yuxia; Huang, Linjuan; Gong, Guiping*; Wang Zhongfu*. NPJ Biofilms Microbiomes, 2023, 9(1): 97.

（14）Zou, Zihua; Wei, Ming; Fang, Jie; Dai, Wei; Sun, Tingting; Liu, Qian; Gong, Guiping; Liu, Yuxia; Song, Shuang; Ma, Fangli; Wang, Langhong; Huang, Linjuan*; Wang, Zhongfu*. Preparation of chondroitin sulfates with different molecular weights from bovine nasal cartilage and their antioxidant activities. International Journal of Biological Macromolecules, 2019, 592, 113355: 1-12.

（15）Gong, Guiping; Dang, Tiantian; Fang, Jie; Deng, Yangni; Liu, Qian; Dai,Wei; Sun, Jing; Wang, Langhong; Liu, Yuxia; Sun, Tingting; Song, Shuang; Fan, Luodi; Huang, Linjuan*; Wang, Zhongfu*. Preparation, structural characterization, and bioactivity of PHPD-IV-4 derived from Porphyra haitanensis. Food Chemistry, 2020, 329: 127042.

（16）Gong, Guiping; Liu, Qian; Deng, Yangni; Dang, Tiantian; Dai, Wei; Liu, Tingting; Liu, Yang; Sun, Jing; Wang, Langhong; Liu, Yuxia; Sun, Tingting; Song, Shuang; Wang, Zhongfu*; Huang, Linjuan*. Arabinogalactan derived from Lycium barbarum fruit inhibits cancer cell growth via cell cycle arrest and apoptosis. International Journal of Biological Macromolecules, 2020, 149: 639-650.

近5年专利或其他成果：

（1）一种合成异喹啉酮类化物的方法，ZL201510534658.5，第二发明人。

（2）一种合成异色酮类化合物的方法，ZL201610348233.X，第二发明人。

（3）一种氰基吡唑啉酮类异二官能团试剂及其在构建糖芯片中的应用，202215772380.7，第一发明人。